HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70

HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70

Abstract Background 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been studied. We aim to investigate the effect of 17AAG on sevoflurane-induced n...

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Bibliographic Details
Main Authors: Min Liu, Moyun Li, Yu Zhou, Qian Zhou, Yugang Jiang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Translational Medicine
Subjects:
Anesthetic neurotoxicity
17-N-allylamino-17-demethoxygeldanamycin (17AAG)
Heat shock protein
Apoptosis
Oxidative stress
NF-κB
Online Access:http://link.springer.com/article/10.1186/s12967-020-02332-w

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