Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency

Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based therapy for TK2-deficiency

Abstract Background Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase small subunit (p53R2) is associated with tissue specific mitochondrial DNA (mtDNA) depletion. To understand the mechanisms of the tissue specific mtDNA depletion we systematically studied key enzymes...

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Bibliographic Details
Main Authors: Liya Wang, Ren Sun, Staffan Eriksson
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Molecular and Cell Biology
Subjects:
Thymidine kinase 2
Thymidylate synthase
p53R2
Mitochondrial DNA depletion
dTMP synthesis; mtDNA
Mitochondrial DNA; RNR
Online Access:http://link.springer.com/article/10.1186/s12860-020-00272-3

Internet

http://link.springer.com/article/10.1186/s12860-020-00272-3

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