Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

Trauma is a leading cause of death worldwide with 5.8 million deaths occurring yearly. Almost 40% of trauma deaths are due to bleeding and occur in the first few hours after injury. Of the remaining severely injured patients up to 25% develop a dysregulated immune response leading to multiple organ...

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Bibliographic Details
Main Authors: Andrew Aswani, Joanna Manson, Kiyoshi Itagaki, Fausto Chiazza, Massimo Collino, Winston Liao Wupeng, Tze Khee Chan, W. S. Fred Wong, Carl J. Hauser, Chris Thiemermann, Karim Brohi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
trauma
mitochondrial DNA
damage-associated molecular patterns
nucleic acid scavenger
multiple organ dysfunction syndrome
trauma hemorrhage
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00891/full

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