Value of serum procalcitonin content in severe acute pancreatitis for evaluating the infection degree and intestinal mucosal barrier function

• Main Authors: Jing Gao, Xi Chen, Mei Yang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-04-01
• Series: Journal of Hainan Medical University
• Subjects: Severe acute pancreatitis; Procalcitonin; Inflammatory response; Intestinal mucosal barrier function
• Online Access: http://www.hnykdxxb.com/PDF/201804/25.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the value of serum procalcitonin content in severe acute pancreatitis for evaluating the infection degree and intestinal mucosal barrier function. Methods: A total of 68 patients with severe acute pancreatitis who were treated in our hospital between January 2015 and September 2017 were selected as pancreatitis group, and 50 healthy volunteers who underwent physical examination in this hospital during the same period were selected as normal control group. The differences in serum levels of PCT, inflammatory factors and intestinal mucosal barrier function indexes were compared between the two groups, and Pearson test was used to evaluate the correlation between PCT content and severe acute pancreatitis. Results: Serum PCT content of pancreatitis group was higher than that of control group; serum IL-6, IL-10 and TNF-α contents were higher than those of control group; serum D-Lactate, DAO and Endotoxin contents were higher than those of control group. Pearson test showed that the serum PCT content of patients with severe acute pancreatitis was directly correlated with the degree of infection and intestinal mucosal barrier dysfunction. Conclusion: Serum PCT content abnormally increases in severe acute pancreatitis, and the specific content is directly correlated with the degree of infection and intestinal mucosal barrier dysfunction.