Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of an...

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Main Authors:	Runming Wang, Tsz-Pui Lai, Peng Gao, Hongmin Zhang, Pak-Leung Ho, Patrick Chiu-Yat Woo, Guixing Ma, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-02828-6

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spelling	doaj-f323b829fd714274aab5e5072828f56c2021-05-11T09:49:36ZengNature Publishing GroupNature Communications2041-17232018-01-019111210.1038/s41467-018-02828-6Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitorsRunming Wang0Tsz-Pui Lai1Peng Gao2Hongmin Zhang3Pak-Leung Ho4Patrick Chiu-Yat Woo5Guixing Ma6Richard Yi-Tsun Kao7Hongyan Li8Hongzhe Sun9Department of Chemistry, The University of Hong KongDepartment of Chemistry, The University of Hong KongDepartment of Microbiology, The University of Hong KongDepartment of Chemistry, The University of Hong KongDepartment of Microbiology, The University of Hong KongDepartment of Microbiology, The University of Hong KongDepartment of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and TechnologyDepartment of Microbiology, The University of Hong KongDepartment of Chemistry, The University of Hong KongDepartment of Chemistry, The University of Hong KongMetallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.https://doi.org/10.1038/s41467-018-02828-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun
spellingShingle	Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors Nature Communications
author_facet	Runming Wang Tsz-Pui Lai Peng Gao Hongmin Zhang Pak-Leung Ho Patrick Chiu-Yat Woo Guixing Ma Richard Yi-Tsun Kao Hongyan Li Hongzhe Sun
author_sort	Runming Wang
title	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_short	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_full	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_fullStr	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_full_unstemmed	Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
title_sort	bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which is of great interest for the development of antibiotics.
url	https://doi.org/10.1038/s41467-018-02828-6
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Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

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