Prefrontal Cortex in Learning to Overcome Generalized Fear

Prefrontal Cortex in Learning to Overcome Generalized Fear

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Normal brain functioning relies critically on the ability to control appropriate behavioral responses to fearful stimuli. Overgeneralized fear is the major symptom of anxiety disorders including posttraumatic stress disorder. This review describes recent data demonstrating that the medial prefrontal...

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Main Author: Edward Korzus
Format: Article
Language:English
Published: SAGE Publishing 2015-01-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.4137/JEN.S26227
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spelling doaj-f316e228c1684ad6b6531a06f5744f552020-11-25T04:00:20ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952015-01-01910.4137/JEN.S26227Prefrontal Cortex in Learning to Overcome Generalized FearEdward Korzus0Department of Psychology, Neuroscience and Biomedical Sciences Programs, University of California Riverside, CA, USA.Normal brain functioning relies critically on the ability to control appropriate behavioral responses to fearful stimuli. Overgeneralized fear is the major symptom of anxiety disorders including posttraumatic stress disorder. This review describes recent data demonstrating that the medial prefrontal cortex (mPFC) plays a critical role in the refining of cues that drive the acquisition of fear response. Recent studies on molecular mechanisms that underlie the role of mPFC in fear discrimination learning are discussed. These studies suggest that prefrontal N-methyl-D-aspartate receptors expressed in excitatory neurons govern fear discrimination learning via a mechanism involving cAMP response element-binding protein-dependent engagement of acetyltransferase.https://doi.org/10.4137/JEN.S26227
collection DOAJ
language English
format Article
sources DOAJ
author Edward Korzus
spellingShingle Edward Korzus
Prefrontal Cortex in Learning to Overcome Generalized Fear
Journal of Experimental Neuroscience
author_facet Edward Korzus
author_sort Edward Korzus
title Prefrontal Cortex in Learning to Overcome Generalized Fear
title_short Prefrontal Cortex in Learning to Overcome Generalized Fear
title_full Prefrontal Cortex in Learning to Overcome Generalized Fear
title_fullStr Prefrontal Cortex in Learning to Overcome Generalized Fear
title_full_unstemmed Prefrontal Cortex in Learning to Overcome Generalized Fear
title_sort prefrontal cortex in learning to overcome generalized fear
publisher SAGE Publishing
series Journal of Experimental Neuroscience
issn 1179-0695
publishDate 2015-01-01
description Normal brain functioning relies critically on the ability to control appropriate behavioral responses to fearful stimuli. Overgeneralized fear is the major symptom of anxiety disorders including posttraumatic stress disorder. This review describes recent data demonstrating that the medial prefrontal cortex (mPFC) plays a critical role in the refining of cues that drive the acquisition of fear response. Recent studies on molecular mechanisms that underlie the role of mPFC in fear discrimination learning are discussed. These studies suggest that prefrontal N-methyl-D-aspartate receptors expressed in excitatory neurons govern fear discrimination learning via a mechanism involving cAMP response element-binding protein-dependent engagement of acetyltransferase.
url https://doi.org/10.4137/JEN.S26227
work_keys_str_mv AT edwardkorzus prefrontalcortexinlearningtoovercomegeneralizedfear
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