Regulatory network structure determines patterns of intermolecular epistasis

Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcr...

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Bibliographic Details
Main Authors: Mato Lagator, Srdjan Sarikas, Hande Acar, Jonathan P Bollback, Călin C Guet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/28921