Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition

Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition

Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in m...

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Main Authors: Theodore Wright, Basak Coruh, David Fredricks, Nina Kim
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Medical Mycology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753918301404
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spelling doaj-f3108dd12ba7422497c838d0f88271132020-11-25T03:40:49ZengElsevierMedical Mycology Case Reports2211-75392019-03-01236264Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibitionTheodore Wright0Basak Coruh1David Fredricks2Nina Kim3Division of Infectious Diseases, University of Washington, Harborview Medical Center, Seattle, WA 98104, United States; Correspondence to: University of Washington, 325 9th Ave, Seattle, WA 98104.Division of Pulmonary and Critical Care, University of Washington, University of Washington Medical Center, Seattle, WA 98104, United StatesDivision of Infectious Diseases, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, United StatesDivision of Infectious Diseases, University of Washington, Harborview Medical Center, Seattle, WA 98104, United StatesEndemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections. Keywords: Immune reconstitution inflammatory syndrome, Histoplasmosis, TNF-alphahttp://www.sciencedirect.com/science/article/pii/S2211753918301404
collection DOAJ
language English
format Article
sources DOAJ
author Theodore Wright
Basak Coruh
David Fredricks
Nina Kim
spellingShingle Theodore Wright
Basak Coruh
David Fredricks
Nina Kim
Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
Medical Mycology Case Reports
author_facet Theodore Wright
Basak Coruh
David Fredricks
Nina Kim
author_sort Theodore Wright
title Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
title_short Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
title_full Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
title_fullStr Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
title_full_unstemmed Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition
title_sort immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and tnf-alpha inhibition
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2019-03-01
description Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections. Keywords: Immune reconstitution inflammatory syndrome, Histoplasmosis, TNF-alpha
url http://www.sciencedirect.com/science/article/pii/S2211753918301404
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AT davidfredricks immunereconstitutioninflammatorysyndromeassociatedwithdisseminatedhistoplasmosisandtnfalphainhibition
AT ninakim immunereconstitutioninflammatorysyndromeassociatedwithdisseminatedhistoplasmosisandtnfalphainhibition
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