Guhong Injection Protects Against Apoptosis in Cerebral Ischemia by Maintaining Cerebral Microvasculature and Mitochondrial Integrity Through the PI3K/AKT Pathway

Guhong Injection Protects Against Apoptosis in Cerebral Ischemia by Maintaining Cerebral Microvasculature and Mitochondrial Integrity Through the PI3K/AKT Pathway

Guhong injection (GHI) can be used for the treatment of ischemic stroke. We investigated the antiapoptotic activity of GHI, its ability to repair the cerebral microvessels and mitochondria, and the PI3K/AKT signaling pathway of GHI against cerebral ischemia. Western blot and immunohistochemical anal...

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Bibliographic Details
Main Authors: Huifen Zhou, Yu He, Jiaqi Zhu, Xiaojie Lin, Juan Chen, Chongyu Shao, Haitong Wan, Jiehong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Guhong injection
ischemic stroke
cerebral microvascular
mitochondria
antiapoptosis
PI3K/Akt pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.650983/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.650983/full

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