Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In thi...

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Main Authors: Emanuele Cannizzaro, Tiziana Ramaci, Luigi Cirrincione, Fulvio Plescia
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Online Access:https://www.mdpi.com/1660-4601/16/20/4031
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spelling doaj-f2fc6639148645a5901f8ca92612dcf42020-11-25T01:44:10ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-10-011620403110.3390/ijerph16204031ijerph16204031Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic FactorsEmanuele Cannizzaro0Tiziana Ramaci1Luigi Cirrincione2Fulvio Plescia3Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyFaculty of Human and Social Sciences, Kore University of Enna, 94100 Enna, ItalyDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyWork-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.https://www.mdpi.com/1660-4601/16/20/4031work-related stressenvironmentgenetic factorsstress
collection DOAJ
language English
format Article
sources DOAJ
author Emanuele Cannizzaro
Tiziana Ramaci
Luigi Cirrincione
Fulvio Plescia
spellingShingle Emanuele Cannizzaro
Tiziana Ramaci
Luigi Cirrincione
Fulvio Plescia
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
International Journal of Environmental Research and Public Health
work-related stress
environment
genetic factors
stress
author_facet Emanuele Cannizzaro
Tiziana Ramaci
Luigi Cirrincione
Fulvio Plescia
author_sort Emanuele Cannizzaro
title Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
title_short Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
title_full Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
title_fullStr Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
title_full_unstemmed Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
title_sort work-related stress, physio-pathological mechanisms, and the influence of environmental genetic factors
publisher MDPI AG
series International Journal of Environmental Research and Public Health
issn 1660-4601
publishDate 2019-10-01
description Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.
topic work-related stress
environment
genetic factors
stress
url https://www.mdpi.com/1660-4601/16/20/4031
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AT fulvioplescia workrelatedstressphysiopathologicalmechanismsandtheinfluenceofenvironmentalgeneticfactors
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