Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In thi...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/16/20/4031 |
id |
doaj-f2fc6639148645a5901f8ca92612dcf4 |
---|---|
record_format |
Article |
spelling |
doaj-f2fc6639148645a5901f8ca92612dcf42020-11-25T01:44:10ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-10-011620403110.3390/ijerph16204031ijerph16204031Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic FactorsEmanuele Cannizzaro0Tiziana Ramaci1Luigi Cirrincione2Fulvio Plescia3Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyFaculty of Human and Social Sciences, Kore University of Enna, 94100 Enna, ItalyDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyDepartment of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, ItalyWork-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.https://www.mdpi.com/1660-4601/16/20/4031work-related stressenvironmentgenetic factorsstress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emanuele Cannizzaro Tiziana Ramaci Luigi Cirrincione Fulvio Plescia |
spellingShingle |
Emanuele Cannizzaro Tiziana Ramaci Luigi Cirrincione Fulvio Plescia Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors International Journal of Environmental Research and Public Health work-related stress environment genetic factors stress |
author_facet |
Emanuele Cannizzaro Tiziana Ramaci Luigi Cirrincione Fulvio Plescia |
author_sort |
Emanuele Cannizzaro |
title |
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors |
title_short |
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors |
title_full |
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors |
title_fullStr |
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors |
title_full_unstemmed |
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors |
title_sort |
work-related stress, physio-pathological mechanisms, and the influence of environmental genetic factors |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2019-10-01 |
description |
Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response. |
topic |
work-related stress environment genetic factors stress |
url |
https://www.mdpi.com/1660-4601/16/20/4031 |
work_keys_str_mv |
AT emanuelecannizzaro workrelatedstressphysiopathologicalmechanismsandtheinfluenceofenvironmentalgeneticfactors AT tizianaramaci workrelatedstressphysiopathologicalmechanismsandtheinfluenceofenvironmentalgeneticfactors AT luigicirrincione workrelatedstressphysiopathologicalmechanismsandtheinfluenceofenvironmentalgeneticfactors AT fulvioplescia workrelatedstressphysiopathologicalmechanismsandtheinfluenceofenvironmentalgeneticfactors |
_version_ |
1725029446876921856 |