Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis

Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis

The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc2 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the t...

Full description

Bibliographic Details
Main Authors: Jyothi Padiadpu, Priyanka Baloni, Nagasuma Chandra
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340915000748
id doaj-f2f4acae77b5468785e3158377e8d894
record_format Article
spelling doaj-f2f4acae77b5468785e3158377e8d8942020-11-25T02:01:43ZengElsevierData in Brief2352-34092015-09-014C18618910.1016/j.dib.2015.05.006Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatisJyothi Padiadpu0Priyanka Baloni1Nagasuma Chandra2Department of Biochemistry, IISc, Bangalore 560012, IndiaDepartment of Biochemistry, IISc, Bangalore 560012, IndiaDepartment of Biochemistry, IISc, Bangalore 560012, IndiaThe global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc2 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the treated conditions have been considered as differentially expressed genes (DEGs). Overall, the numbers of DEGs observed are 1529 in ½X (596—up, 933—down), 1381 (899—up, 482—down) in 2XR and 716 in 4XR (267—up, 449—down) conditions. The data is publicly available through the GEO database with accession number GSE64132.http://www.sciencedirect.com/science/article/pii/S2352340915000748
collection DOAJ
language English
format Article
sources DOAJ
author Jyothi Padiadpu
Priyanka Baloni
Nagasuma Chandra
spellingShingle Jyothi Padiadpu
Priyanka Baloni
Nagasuma Chandra
Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
Data in Brief
author_facet Jyothi Padiadpu
Priyanka Baloni
Nagasuma Chandra
author_sort Jyothi Padiadpu
title Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
title_short Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
title_full Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
title_fullStr Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
title_full_unstemmed Gene expression profiles of wild-type and isoniazid-resistant strains of Mycobacterium smegmatis
title_sort gene expression profiles of wild-type and isoniazid-resistant strains of mycobacterium smegmatis
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2015-09-01
description The global variations in the gene expression pattern of drug treated (½X) and laboratory evolved drug-resistant strains (2XR and 4XR) of Mycobacterium smegmatis were obtained and compared with the M. smegmatis mc2 155 (WT) strain. The genes exhibiting two-fold change and p-value <0.05 under the treated conditions have been considered as differentially expressed genes (DEGs). Overall, the numbers of DEGs observed are 1529 in ½X (596—up, 933—down), 1381 (899—up, 482—down) in 2XR and 716 in 4XR (267—up, 449—down) conditions. The data is publicly available through the GEO database with accession number GSE64132.
url http://www.sciencedirect.com/science/article/pii/S2352340915000748
work_keys_str_mv AT jyothipadiadpu geneexpressionprofilesofwildtypeandisoniazidresistantstrainsofmycobacteriumsmegmatis
AT priyankabaloni geneexpressionprofilesofwildtypeandisoniazidresistantstrainsofmycobacteriumsmegmatis
AT nagasumachandra geneexpressionprofilesofwildtypeandisoniazidresistantstrainsofmycobacteriumsmegmatis
_version_ 1724956214748512256

Similar Items