JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages

JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages

A substitution mutation of valine to phenylalanine at codon encoding position 617 of the Janus kinase 2 (JAK2) gene (JAK2V617F) has been detected in myeloid cells of some individuals with higher levels of proinflammatory cytokine production such as interleukin (IL)-6. However, the mechanisms by whic...

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Bibliographic Details
Main Authors: Rongqing Li, Na Sun, Xin Chen, Xueqin Li, Jie Zhao, Wanpeng Cheng, Hui Hua, Masahiko Fukatsu, Hirotaka Mori, Hiroshi Takahashi, Hiroshi Ohkawara, Miwa Fukami, Masatoshi Okamoto, Yoichi Hamazaki, Kuiyang Zheng, Jing Yang, Takayuki Ikezoe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
JAK2V617F
glycolysis
PKM1
STAT3
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.589048/full

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