Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel

Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel

Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited source of differentiated cells from individuals with specific genetic backgrounds. Using self-replicative RNA reprogramming technology, we generated nine iPSC lines from endothelial progenitor cells (EPCs) derived from bloo...

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Main Authors: Xiugong Gao, Jeffrey J. Yourick, Robert L. Sprando
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118301818
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spelling doaj-f2e24709b3924e8e899f22c81b51f8722020-11-24T22:07:31ZengElsevierStem Cell Research1873-50612018-08-0131193196Generation of nine induced pluripotent stem cell lines as an ethnic diversity panelXiugong Gao0Jeffrey J. Yourick1Robert L. Sprando2Corresponding author.; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited source of differentiated cells from individuals with specific genetic backgrounds. Using self-replicative RNA reprogramming technology, we generated nine iPSC lines from endothelial progenitor cells (EPCs) derived from blood samples of three different ethnicities: Black or African American, Latino or Hispanic, and Non-Hispanic White. The resulting iPSC lines showed normal karyotype in large part, expressed pluripotency marker genes, and spontaneously differentiated in vitro into the three germ layers. These iPSC lines offer the potential to generate tissues with ethnic diversity, and thus afford a valuable tool for ethnic-related toxicological applications.http://www.sciencedirect.com/science/article/pii/S1873506118301818
collection DOAJ
language English
format Article
sources DOAJ
author Xiugong Gao
Jeffrey J. Yourick
Robert L. Sprando
spellingShingle Xiugong Gao
Jeffrey J. Yourick
Robert L. Sprando
Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
Stem Cell Research
author_facet Xiugong Gao
Jeffrey J. Yourick
Robert L. Sprando
author_sort Xiugong Gao
title Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
title_short Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
title_full Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
title_fullStr Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
title_full_unstemmed Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
title_sort generation of nine induced pluripotent stem cell lines as an ethnic diversity panel
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2018-08-01
description Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited source of differentiated cells from individuals with specific genetic backgrounds. Using self-replicative RNA reprogramming technology, we generated nine iPSC lines from endothelial progenitor cells (EPCs) derived from blood samples of three different ethnicities: Black or African American, Latino or Hispanic, and Non-Hispanic White. The resulting iPSC lines showed normal karyotype in large part, expressed pluripotency marker genes, and spontaneously differentiated in vitro into the three germ layers. These iPSC lines offer the potential to generate tissues with ethnic diversity, and thus afford a valuable tool for ethnic-related toxicological applications.
url http://www.sciencedirect.com/science/article/pii/S1873506118301818
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AT jeffreyjyourick generationofnineinducedpluripotentstemcelllinesasanethnicdiversitypanel
AT robertlsprando generationofnineinducedpluripotentstemcelllinesasanethnicdiversitypanel
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