Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

• Main Authors: Shanmugavel Chinnathambi, Fuyuhiko Tamanoi
• Format: Article
• Language: English
• Published: MDPI AG 2020-09-01
• Series: Pharmaceutics
• Subjects: PMOs; biodegradable; drug delivery; cancer targeting and treatment
• Online Access: https://www.mdpi.com/1999-4923/12/9/890

Porous nanomaterials can be used to load various anti-cancer drugs efficiently and deliver them to a particular location in the body with minimal toxicity. Biodegradable periodic mesoporous organosilica nanoparticles (BPMOs) have recently emerged as promising candidates for disease targeting and drug delivery. They have a large functional surface and well-defined pores with a biodegradable organic group framework. Multiple biodegradation methods have been explored, such as the use of redox, pH, enzymatic activity, and light. Various drug delivery systems using BPMO have been developed. This review describes recent advances in the biomedical application of BPMOs.