Immunogenic Cell Death by the Novel Topoisomerase I Inhibitor TLC388 Enhances the Therapeutic Efficacy of Radiotherapy

Immunogenic Cell Death by the Novel Topoisomerase I Inhibitor TLC388 Enhances the Therapeutic Efficacy of Radiotherapy

Rectal cancer accounts for 30–40% of colorectal cancer (CRC) and is the most common cancer-related death worldwide. The preoperative neoadjuvant chemoradiotherapy (neoCRT) regimen is the main therapeutic strategy for patients with locally advanced rectal cancer (LARC) to control tumor growth and red...

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Bibliographic Details
Main Authors: Kevin Chih-Yang Huang, Shu-Fen Chiang, Pei-Chen Yang, Tao-Wei Ke, Tsung-Wei Chen, Ching-Han Hu, Yi-Wen Huang, Hsin-Yu Chang, William Tzu-Liang Chen, K. S. Clifford Chao
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
locally advanced rectal cancer
neoadjuvant chemoradiotherapy
topoisomerase I inhibitor
lipotecan
anticancer immunity
Online Access:https://www.mdpi.com/2072-6694/13/6/1218

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