Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension

Background: Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and remodeling of the lung vasculature. Adenosine signaling through the ADORA2B receptor has previously been implicated in diseas...

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Bibliographic Details
Main Authors: Tinne C. J. Mertens, Ankit Hanmandlu, Ly Tu, Carole Phan, Scott D. Collum, Ning-Yuan Chen, Tingting Weng, Jonathan Davies, Chen Liu, Holger K. Eltzschig, Soma S. K. Jyothula, Keshava Rajagopal, Yang Xia, Ashrith Guha, Brian A. Bruckner, Michael R. Blackburn, Christophe Guignabert, Harry Karmouty-Quintana
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
Group I PH
Group III PH
hyaluronan
tissue transglutaminase
lung fibrosis
vascular remodeling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00555/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00555/full

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