Pathological Aspects of Neuronal Hyperploidization in Alzheimer’s Disease Evidenced by Computer Simulation
When subjected to stress, terminally differentiated neurons are susceptible to reactivate the cell cycle and become hyperploid. This process is well documented in Alzheimer’s disease (AD), where it may participate in the etiology of the disease. However, despite its potential importance, the effects...
Main Authors: | Estíbaliz Barrio-Alonso, Bérénice Fontana, Manuel Valero, José M. Frade |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-03-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2020.00287/full |
Similar Items
-
Optimizing of Large T Antigen for Designing and Constructing Episomal Plasmid Based on Mutated Large T Antigen Simian Virus 40
by: Mohammad Reza Asgharzadeh, et al.
Published: (2013-06-01) -
SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction
by: Joshua B. Reus, et al.
Published: (2020-01-01) -
Establishment of an immortalized mouse dermal papilla cell strain with optimized culture strategy
by: Haiying Guo, et al.
Published: (2018-01-01) -
Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system
by: Tet Woo eLee, et al.
Published: (2015-10-01) -
Study of SV40 large T antigen nucleotide specificity for DNA unwinding
by: Damian Wang, et al.
Published: (2017-04-01)