Endothelin type A receptor genotype is a determinant of quantitative traits of metabolic syndrome in Asian hypertensive families: a SAPPHIRe study

• Main Author: Low-Tone eHo
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2013-11-01
• Series: Frontiers in Endocrinology
• Subjects: Insulin Resistance; metabolic syndrome; ethnicity; Endothelin type A receptor; rs5333 polymorphlism; Sib-pairs
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00172/full

Co-heritability of hypertension and insulin resistance within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome. Thus we determined whether the T323C polymorphism (rs5333) of endothlein type A (ETA) receptor, a predominant receptor evoking potent vasoconstrictive action of endothelin-1, contributes to susceptibility to insulin resistance-associated hypertension in 1,694 subjects of Chinese and Japanese origins. Blood pressures and biochemistries were measured. Fasting insulin level, insulin-resistance homeostasis model assessment (HOMAIR) score, and area under curve of insulin concentration (AUCINS) were selected for assessing insulin sensitivity. Genotypes were obtained by methods of PCR-RFLP. Foremost findings were that minor allele frequency of the T323C polymorphism was noticeable lower in our overall Asian subjects compared to multi-national population reported in gene database; moreover both the genotypic and allelic frequencies of the polymorphism were significantly different between the two ethnic groups we studied. The genotype distributions at TT/TC/CC were 65%, 31%, 4% in Chinese and 51%, 41%, 8% in Japanese, respectively (p