| Summary: | Co-heritability of hypertension and insulin resistance within families not only implies genetic susceptibility may be responsible for these complex traits but also suggests a rational that biological candidate genes for hypertension may serve as markers for features of the metabolic syndrome. Thus we determined whether the T323C polymorphism (rs5333) of endothlein type A (ETA) receptor, a predominant receptor evoking potent vasoconstrictive action of endothelin-1, contributes to susceptibility to insulin resistance-associated hypertension in 1,694 subjects of Chinese and Japanese origins. Blood pressures and biochemistries were measured. Fasting insulin level, insulin-resistance homeostasis model assessment (HOMAIR) score, and area under curve of insulin concentration (AUCINS) were selected for assessing insulin sensitivity. Genotypes were obtained by methods of PCR-RFLP. Foremost findings were that minor allele frequency of the T323C polymorphism was noticeable lower in our overall Asian subjects compared to multi-national population reported in gene database; moreover both the genotypic and allelic frequencies of the polymorphism were significantly different between the two ethnic groups we studied. The genotype distributions at TT/TC/CC were 65%, 31%, 4% in Chinese and 51%, 41%, 8% in Japanese, respectively (p
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