Exploring links between vitamin D deficiency and COVID-19.

• Main Authors: Mradul Mohan, Jerin Jose Cherian, Amit Sharma
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2020-09-01
• Series: PLoS Pathogens
• Online Access: https://doi.org/10.1371/journal.ppat.1008874

Coronavirus Disease 2019 (COVID-19) pandemic remains a major public health threat in most countries. The causative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to acute respiratory distress syndrome and result in mortality in COVID-19 patients. Vitamin D is an immunomodulator hormone with established effectiveness against various upper respiratory infections. Vitamin D can stall hyper-inflammatory responses and expedite healing process of the affected areas, primarily in the lung tissue. Thus, there are ecological and mechanistic reasons to promote exploration of vitamin D action in COVID-19 patients. As no curative drugs are available currently for COVID-19, we feel that the potential of vitamin D to alter the course of disease severity needs to be investigated. Clinical studies may be undertaken to address the value of vitamin D supplementation in deficient, high-risk COVID-19 patients.