What parameters affect left ventricular diastolic flow propagation velocity? in vitro studies using color m-mode doppler echocardiography

• Main Authors: Bess Renee L, Yoganathan Ajit P, Walker David K, Scotten Lawrence N, Ogawa Toshihiro, Nordstrom Cheryl K, Gardin Julius M
• Format: Article
• Language: English
• Published: BMC 2005-09-01
• Series: Cardiovascular Ultrasound
• Online Access: http://www.cardiovascularultrasound.com/content/3/1/24
• ISSN: 1476-7120

<p>Abstract</p> <p>Background</p> <p>Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.</p> <p>Methods</p> <p>An in vitro LV model used to simulate LV diastolic inflow with Vp measured under conditions of varying: 1) Stroke volume, 2) heart rate (HR), 3) LV volume, 4) LV compliance, and 5) transmitral flow (TMF) waveforms (Type 1: constant low diastasis flow and Type 2: no diastasis flow).</p> <p>Results</p> <p>Univariate analysis revealed excellent correlations of Vp with stroke volume (r = 0.98), LV compliance (r = 0.94), and HR with Type 1 TMF (r = 0.97). However, with Type 2 TMF, HR was not associated with Vp. LV volume was not related to Vp under low compliance, but inversely related to Vp under high compliance conditions (r = -0.56).</p> <p>Conclusion</p> <p>These in vitro findings may help elucidate the relationship of hemodynamic parameters to early diastolic LV filling.</p>