Synthesis and Rational Design of New Appended 1,2,3-Triazole-Uracil Ensembles as Promising Anti-Tumor Agents via In Silico VEGFR-2 Transferase Inhibition

Synthesis and Rational Design of New Appended 1,2,3-Triazole-Uracil Ensembles as Promising Anti-Tumor Agents via In Silico VEGFR-2 Transferase Inhibition

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles <b>5a</b>–<b>r</b> were designed and synthesized via the click reaction. Th...

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Bibliographic Details
Main Authors: Nadipolla Naresh Reddy, Sung-Jen Hung, Merugu Kumara Swamy, Ananthula Sanjeev, Vankadari Srinivasa Rao, Rondla Rohini, Atcha Krishnam Raju, Kuthati Bhaskar, Anren Hu, Puchakayala Muralidhar Reddy
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
drug design
1,2,3-triazole-uracil
VEGFR-2
in silico docking
MTT assay
anti-cancer agents
Online Access:https://www.mdpi.com/1420-3049/26/7/1952

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