Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines.

Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines.

Activation of the stem cell transcriptional circuitry is an important event in cancer development. Although cancer cells demonstrate a stem cell-like gene expression signature, the epigenetic regulation of pluripotency-associated genes in cancers remains poorly understood. In this study, we characte...

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Bibliographic Details
Main Authors: Xiao Qi Wang, Ray Kit Ng, Xiaoyan Ming, Wu Zhang, Lin Chen, Andrew C Y Chu, Roberta Pang, Chung Mau Lo, Sai Wah Tsao, Xuqing Liu, Ronnie T P Poon, Sheung Tat Fan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3762826?pdf=render

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