The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

The regioselective three-component condensation of azomethine ylides derived from isatins and α-amino acids with acrylamides or aroylacrylic acids as dipolarophiles has been realized through a one-pot 1,3-dipolar cycloaddition protocol. Decarboxylation of 2'-aroyl-2-oxo-1,1',2,2',5�...

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Bibliographic Details
Main Authors: Tatyana L. Pavlovskaya, Fedor G. Yaremenko, Victoria V. Lipson, Svetlana V. Shishkina, Oleg V. Shishkin, Vladimir I. Musatov, Alexander S. Karpenko
Format: Article
Language:English
Published: Beilstein-Institut 2014-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acrylamides
aroylacrylic acids
azomethine ylide
cyclative rearrangement
cycloaddition
multicomponent
spirooxindoles
Online Access:https://doi.org/10.3762/bjoc.10.8

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