Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

• Main Authors: Rafael Affini Martins, Dandara Cassu-Corsi, Carolina Silva Nodari, Rodrigo Cayô, Larissa Natsumeda, Ana Paula Streling, André Mario Doi, Roberto José Carvalho da Silva, Roberta Alessandra Lima Bocalon, Ana Cristina Gales, Antonio Carlos Campos Pignatari
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Neisseria gonorrhoeae; antimicrobial resistance temporal evolution; azithromycin; ciprofloxacin-non-susceptible
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100414&lng=en&tlng=en
• ISSN: 1678-8060

A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).