Solvent Free Three-Component Synthesis of 2,4,5-trisubstituted-1<i>H</i>-pyrrol-3-ol-type Compounds from <i>L</i>-tryptophan: DFT-B3LYP Calculations for the Reaction Mechanism and 3<i>H</i>-pyrrol-3-one↔1<i>H</i>-pyrrol-3-ol Tautomeric Equilibrium
In this paper, we describe the solvent-free three-component synthesis of 2,4,5-trisubstituted-1<i>H</i>-pyrrol-3-ol-type compounds from <i>L</i>-tryptophan. The first step of the synthetic methodology involved the esterification of <i>L</i>-tryptophan in excellent...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/19/4402 |