Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels

Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels

Synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein in intraneuronal inclusions, named Lewy bodies. Mutations in GBA1, the gene encoding the lysosomal hydrolase glucocerebrosidase, have been ident...

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Bibliographic Details
Main Authors: Anna Lisa Gündner, Gonzalo Duran-Pacheco, Silke Zimmermann, Iris Ruf, Tim Moors, Karlheinz Baumann, Ravi Jagasia, Wilma D.J. van de Berg, Thomas Kremer
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305941

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