A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.

Bibliographic Details
Main Authors: Donghai Xiong, Yian Wang, Ming You
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18546-x
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spelling doaj-f272e035b0804ec2a83b8daf7b11d3462021-10-10T11:47:54ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-18546-xA gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy responseDonghai Xiong0Yian Wang1Ming You2Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of WisconsinCenter for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of WisconsinCenter for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of WisconsinMost cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.https://doi.org/10.1038/s41467-020-18546-x
collection DOAJ
language English
format Article
sources DOAJ
author Donghai Xiong
Yian Wang
Ming You
spellingShingle Donghai Xiong
Yian Wang
Ming You
A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
Nature Communications
author_facet Donghai Xiong
Yian Wang
Ming You
author_sort Donghai Xiong
title A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_short A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_full A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_fullStr A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_full_unstemmed A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_sort gene expression signature of trem2hi macrophages and γδ t cells predicts immunotherapy response
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.
url https://doi.org/10.1038/s41467-020-18546-x
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AT yianwang ageneexpressionsignatureoftrem2himacrophagesandgdtcellspredictsimmunotherapyresponse
AT mingyou ageneexpressionsignatureoftrem2himacrophagesandgdtcellspredictsimmunotherapyresponse
AT donghaixiong geneexpressionsignatureoftrem2himacrophagesandgdtcellspredictsimmunotherapyresponse
AT yianwang geneexpressionsignatureoftrem2himacrophagesandgdtcellspredictsimmunotherapyresponse
AT mingyou geneexpressionsignatureoftrem2himacrophagesandgdtcellspredictsimmunotherapyresponse
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