Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytok...

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Bibliographic Details
Main Authors: Jennifer L. Johnson, Mahalakshmi Ramadass, Ariela Haimovich, Matthew D. McGeough, Jinzhong Zhang, Hal M. Hoffman, Sergio D. Catz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
inflammasome
exocytosis
neutrophil
inflammation
azurophilic granule
interleukin-1
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00507/full

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00507/full

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