Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis
Abstract Nowadays B-cell depletion via anti-CD20 antibodies is commonly applied in the treatment of multiple sclerosis (MS). Yet, not much is known about infection risks associated with long-term B-cell depletion in the specific context of MS. We present the case of a 45-year-old male patient who de...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-10-01
|
Series: | Neurological Research and Practice |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s42466-020-00074-0 |
id |
doaj-f25077feae5d4bdf844704164060bbef |
---|---|
record_format |
Article |
spelling |
doaj-f25077feae5d4bdf844704164060bbef2020-11-25T02:25:45ZengBMCNeurological Research and Practice2524-34892020-10-01211310.1186/s42466-020-00074-0Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosisCarolin Schwake0Ralf Gold1Department of Neurology, St. Josef-Hospital, Ruhr-University BochumDepartment of Neurology, St. Josef-Hospital, Ruhr-University BochumAbstract Nowadays B-cell depletion via anti-CD20 antibodies is commonly applied in the treatment of multiple sclerosis (MS). Yet, not much is known about infection risks associated with long-term B-cell depletion in the specific context of MS. We present the case of a 45-year-old male patient who developed severe pneumonia following 6 years of rituximab treatment for highly active relapsing-remitting MS. The patient had no additional chronic disease as well as no history of foreign travel. Although the unusual formation of a pulmonary cavity raised suspicion for tuberculosis, repeated testing via bronchoscopy and sputum remained negative. Prolonged antibiotic therapy with piperacillin/tazobactam and amoxicillin/ clavulanate led to complete recovery from symptoms. This case shows the potential risk of serious infections following continuous B-cell depletion in MS and illustrates the importance of future vigilance.http://link.springer.com/article/10.1186/s42466-020-00074-0Multiple sclerosisRituximabPneumoniaPulmonary cavity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carolin Schwake Ralf Gold |
spellingShingle |
Carolin Schwake Ralf Gold Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis Neurological Research and Practice Multiple sclerosis Rituximab Pneumonia Pulmonary cavity |
author_facet |
Carolin Schwake Ralf Gold |
author_sort |
Carolin Schwake |
title |
Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
title_short |
Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
title_full |
Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
title_fullStr |
Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
title_full_unstemmed |
Severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
title_sort |
severe pneumonia with formation of a pulmonary cavity associated with long-term rituximab therapy in multiple sclerosis |
publisher |
BMC |
series |
Neurological Research and Practice |
issn |
2524-3489 |
publishDate |
2020-10-01 |
description |
Abstract Nowadays B-cell depletion via anti-CD20 antibodies is commonly applied in the treatment of multiple sclerosis (MS). Yet, not much is known about infection risks associated with long-term B-cell depletion in the specific context of MS. We present the case of a 45-year-old male patient who developed severe pneumonia following 6 years of rituximab treatment for highly active relapsing-remitting MS. The patient had no additional chronic disease as well as no history of foreign travel. Although the unusual formation of a pulmonary cavity raised suspicion for tuberculosis, repeated testing via bronchoscopy and sputum remained negative. Prolonged antibiotic therapy with piperacillin/tazobactam and amoxicillin/ clavulanate led to complete recovery from symptoms. This case shows the potential risk of serious infections following continuous B-cell depletion in MS and illustrates the importance of future vigilance. |
topic |
Multiple sclerosis Rituximab Pneumonia Pulmonary cavity |
url |
http://link.springer.com/article/10.1186/s42466-020-00074-0 |
work_keys_str_mv |
AT carolinschwake severepneumoniawithformationofapulmonarycavityassociatedwithlongtermrituximabtherapyinmultiplesclerosis AT ralfgold severepneumoniawithformationofapulmonarycavityassociatedwithlongtermrituximabtherapyinmultiplesclerosis |
_version_ |
1724850343180763136 |