Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties

Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties

Abstract Background Food is known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs. Although food is known to affect the pharmacokinetics of oral antineoplastic dru...

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Bibliographic Details
Main Authors: Fukiko Omachi, Masaki Kaneko, Ryosuke Iijima, Machiko Watanabe, Fumio Itagaki
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Food effects
Oral antineoplastic drugs
Pharmacokinetics
Physicochemical properties
In silico
Online Access:https://doi.org/10.1186/s40780-019-0155-1

Internet

https://doi.org/10.1186/s40780-019-0155-1

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