MiR-101 induces senescence and prevents apoptosis in the background of DNA damage in MCF7 cells.

MiR-101 induces senescence and prevents apoptosis in the background of DNA damage in MCF7 cells.

Moderately increased DNA damage due to the exogenous miR-101 (4 fold) over-expression in MCF7 cells was substantiated by an increase in the number of γ-H2AX foci, correlating with a simple-to-do Halo-assay. miR-101 induced mild/moderate DNA damage favoured senescence rather than apoptosis. An experi...

Full description

Bibliographic Details
Main Authors: Siddharth Manvati, Kailash Chandra Mangalhara, P Kalaiarasan, Niloo Srivastava, Bhupender Kumar, R N K Bamezai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4213038?pdf=render

Similar Items

Similar Items