MOLECULAR FACTORS WITH PREDICTIVE VALUE FOR THE SURVIVAL RATE IN PANCREATIC CANCER: FOCUSING ON CA 19-9

• Main Authors: Daniel Timofte, Radu Danila, Alin Ciobica, Corneliu Diaconu, Roxana Livadaru, Lidia Ionescu
• Format: Article
• Language: English
• Published: "Alexandru Ioan Cuza" University of Iași 2014-09-01
• Series: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
• Online Access: http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/1132

The incidence of pancreatic neoplasm has increased exponentially over the last decades in many parts of the world, and moreover it has become the fifth or even sixth cause of death by cancer in the Western countries. Still, little is known about this disease, since the main disadvantage encountered in pancreatic cancer is the fact that the diagnosis is established too late despite the development of new technologies, while also most of the studies carried out have not been able to identify the significant risk factors for pancreatic. In this way, in the present mini-review we want it to make a short description for the main molecular factors with predictive value for the survival rate in pancreatic cancer and by focusing especially on the CA 19-9. Thus, it seems that CA 19-9 should enter in the arsenal of methods for monitoring the condition of the operated patients and also be a tool for the prognostic evaluations. Also, some of the results we describe here are suggesting that tumor-metastatic involvement of LN 8a can be a strong predictive factor of aggressive tumor biology and, therefore, of the early existence of metastatic disease.