Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-ter...

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Main Authors: Maria-Patapia Zafeiriou, Guobin Bao, James Hudson, Rashi Halder, Alica Blenkle, Marie-Kristin Schreiber, Andre Fischer, Detlev Schild, Wolfram-Hubertus Zimmermann
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17521-w
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spelling doaj-f2273b0bcbe64fb79978e872f203e52e2021-08-01T11:40:28ZengNature Publishing GroupNature Communications2041-17232020-07-0111111210.1038/s41467-020-17521-wDevelopmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal OrganoidsMaria-Patapia Zafeiriou0Guobin Bao1James Hudson2Rashi Halder3Alica Blenkle4Marie-Kristin Schreiber5Andre Fischer6Detlev Schild7Wolfram-Hubertus Zimmermann8Institute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityInstitute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityInstitute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityLuxembourg Centre for Systems Biomedicine, University of LuxembourgInstitute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityInstitute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityCluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of GöttingenInstitute of Neurophysiology and Cellular Biophysics, University Medical Center, Georg-August-UniversityInstitute of Pharmacology and Toxicology, University Medical Center, Georg-August-UniversityBrain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.https://doi.org/10.1038/s41467-020-17521-w
collection DOAJ
language English
format Article
sources DOAJ
author Maria-Patapia Zafeiriou
Guobin Bao
James Hudson
Rashi Halder
Alica Blenkle
Marie-Kristin Schreiber
Andre Fischer
Detlev Schild
Wolfram-Hubertus Zimmermann
spellingShingle Maria-Patapia Zafeiriou
Guobin Bao
James Hudson
Rashi Halder
Alica Blenkle
Marie-Kristin Schreiber
Andre Fischer
Detlev Schild
Wolfram-Hubertus Zimmermann
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
Nature Communications
author_facet Maria-Patapia Zafeiriou
Guobin Bao
James Hudson
Rashi Halder
Alica Blenkle
Marie-Kristin Schreiber
Andre Fischer
Detlev Schild
Wolfram-Hubertus Zimmermann
author_sort Maria-Patapia Zafeiriou
title Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_short Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_full Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_fullStr Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_full_unstemmed Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_sort developmental gaba polarity switch and neuronal plasticity in bioengineered neuronal organoids
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.
url https://doi.org/10.1038/s41467-020-17521-w
work_keys_str_mv AT mariapatapiazafeiriou developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
AT guobinbao developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
AT jameshudson developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
AT rashihalder developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
AT alicablenkle developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
AT mariekristinschreiber developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
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AT wolframhubertuszimmermann developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
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