Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs—Implication for Herb-Drug Interaction

Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs—Implication for Herb-Drug Interaction

Seven medicinal plants popularly used for treating malaria in West Africa were selected to assess herb-drug interaction potential through a series of in vitro methods. Fluorescent cytochrome P450 (CYP) assays were conducted using the recombinant CYP enzymes for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C1...

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Bibliographic Details
Main Authors:	Pius S. Fasinu, Vamshi K. Manda, Olivia R. Dale, Nosa O. Egiebor, Larry A. Walker, Shabana I. Khan
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	Molecules
Subjects:	cytochrome P450 drug metabolism enzyme induction herb-drug interaction herbal medicine malaria P-glycoprotein pregnane-X factor
Online Access:	https://www.mdpi.com/1420-3049/22/12/2049

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