Study on the formulation and characterization of a photoprotective cream containing a new synthetized compound

• Main Authors: Teodora Dalila Balaci, Emma Adriana Ozon, Daniela Luiza Baconi, Georgiana Nițulescu, Bruno Velescu, Cristian Bălălău, Ioana Păunică, Cătălina Ancuța Fița
• Format: Article
• Language: English
• Published: Ion Motofei, Carol Davila University 2020-10-01
• Series: Journal of Mind and Medical Sciences
• Subjects: p-aminosalicylic acid; 2; 6– dichloroacetanilide; acute toxicity study; photoprotective compound; nanostructured lipid carriers
• Online Access: https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1245&context=jmms

Starting from a new organic sunscreen synthesized in our laboratory by the condensation of sodium salt of the p-aminosalicylic acid with 2,6 – dichloroacetanilide, efficient cosmetic formulation with broad photoprotective properties was obtained by using the new compound as organic UV filter, metal oxides as inorganic filters, and vegetable extracts, oils and other ingredients with emollient, protective, and moisturizing effect. After showing the lack of toxicity of the new compound, in order to reduce the amount of UV filter used, it was encapsulated into nanostructured lipid carriers (NLCs). The final cream has demonstrated good qualities for skin application, possessing suitable physicochemical characteristics (pH, viscosity) and spreadability. The SPF value of the product is 16, a value considered to be satisfactory.