miR-29b contributes to multiple types of muscle atrophy

miR-29b contributes to multiple types of muscle atrophy

Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.

Bibliographic Details
Main Authors: Jin Li, Mun Chun Chan, Yan Yu, Yihua Bei, Ping Chen, Qiulian Zhou, Liming Cheng, Lei Chen, Olivia Ziegler, Glenn C. Rowe, Saumya Das, Junjie Xiao
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15201
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spelling doaj-f21c58614d2245499face880f447ae552021-05-11T07:54:05ZengNature Publishing GroupNature Communications2041-17232017-05-018111510.1038/ncomms15201miR-29b contributes to multiple types of muscle atrophyJin Li0Mun Chun Chan1Yan Yu2Yihua Bei3Ping Chen4Qiulian Zhou5Liming Cheng6Lei Chen7Olivia Ziegler8Glenn C. Rowe9Saumya Das10Junjie Xiao11Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai UniversityCardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolDepartment of Spine Surgery, Tongji Hospital, Tongji University School of MedicineCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai UniversityCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai UniversityCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai UniversityDepartment of Spine Surgery, Tongji Hospital, Tongji University School of MedicineDepartment of Spine Surgery, Tongji Hospital, Tongji University School of MedicineCardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolDepartment of Medicine, The University of Alabama at BirminghamCardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolCardiac Regeneration and Ageing Lab, School of Life Science, Shanghai UniversitySkeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.https://doi.org/10.1038/ncomms15201
collection DOAJ
language English
format Article
sources DOAJ
author Jin Li
Mun Chun Chan
Yan Yu
Yihua Bei
Ping Chen
Qiulian Zhou
Liming Cheng
Lei Chen
Olivia Ziegler
Glenn C. Rowe
Saumya Das
Junjie Xiao
spellingShingle Jin Li
Mun Chun Chan
Yan Yu
Yihua Bei
Ping Chen
Qiulian Zhou
Liming Cheng
Lei Chen
Olivia Ziegler
Glenn C. Rowe
Saumya Das
Junjie Xiao
miR-29b contributes to multiple types of muscle atrophy
Nature Communications
author_facet Jin Li
Mun Chun Chan
Yan Yu
Yihua Bei
Ping Chen
Qiulian Zhou
Liming Cheng
Lei Chen
Olivia Ziegler
Glenn C. Rowe
Saumya Das
Junjie Xiao
author_sort Jin Li
title miR-29b contributes to multiple types of muscle atrophy
title_short miR-29b contributes to multiple types of muscle atrophy
title_full miR-29b contributes to multiple types of muscle atrophy
title_fullStr miR-29b contributes to multiple types of muscle atrophy
title_full_unstemmed miR-29b contributes to multiple types of muscle atrophy
title_sort mir-29b contributes to multiple types of muscle atrophy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.
url https://doi.org/10.1038/ncomms15201
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