miR-29b contributes to multiple types of muscle atrophy
Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.
Bibliographic Details
| Main Authors: |
Jin Li,
Mun Chun Chan,
Yan Yu,
Yihua Bei,
Ping Chen,
Qiulian Zhou,
Liming Cheng,
Lei Chen,
Olivia Ziegler,
Glenn C. Rowe,
Saumya Das,
Junjie Xiao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15201
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