NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor pr...

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Main Authors:	Alexandre Dubrac, Steffen E. Künzel, Sandrine H. Künzel, Jinyu Li, Rachana Radhamani Chandran, Kathleen Martin, Daniel M. Greif, Ralf H. Adams, Anne Eichmann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05926-7

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spelling	doaj-f212c5aa389b4f57a14e393ebd8caa172021-05-11T10:25:27ZengNature Publishing GroupNature Communications2041-17232018-08-019111510.1038/s41467-018-05926-7NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathyAlexandre Dubrac0Steffen E. Künzel1Sandrine H. Künzel2Jinyu Li3Rachana Radhamani Chandran4Kathleen Martin5Daniel M. Greif6Ralf H. Adams7Anne Eichmann8Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicineDepartment of Tissue Morphogenesis and University of Münster, Faculty of Medicine, Max Planck Institute for Molecular BiomedicineDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of MedicinePericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.https://doi.org/10.1038/s41467-018-05926-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann
spellingShingle	Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy Nature Communications
author_facet	Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann
author_sort	Alexandre Dubrac
title	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_short	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_full	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_fullStr	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_full_unstemmed	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_sort	nck-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.
url	https://doi.org/10.1038/s41467-018-05926-7
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NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

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