Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling of long-lived Drosophila dilp2-3,5 mutants, and i...

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Bibliographic Details
Main Authors: Luke Stephen Tain, Robert Sehlke, Ralf Leslie Meilenbrock, Thomas Leech, Jonathan Paulitz, Manopriya Chokkalingam, Nagarjuna Nagaraj, Sebastian Grönke, Jenny Fröhlich, Ilian Atanassov, Matthias Mann, Andreas Beyer, Linda Partridge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
lifespan
proteomics
transcriptomics
gene expression
DNA damage
mannosidase
Online Access:https://elifesciences.org/articles/67275

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