Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.

Bibliographic Details
Main Authors:	Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13915-7

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spelling	doaj-f202e0a95a5045ca81301d8ebb687ecf2021-01-31T12:57:02ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-13915-7Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancerKatharina von Loga0Andrew Woolston1Marco Punta2Louise J. Barber3Beatrice Griffiths4Maria Semiannikova5Georgia Spain6Benjamin Challoner7Kerry Fenwick8Ronald Simon9Andreas Marx10Guido Sauter11Stefano Lise12Nik Matthews13Marco Gerlinger14Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchBioinformatics Core, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTumour Profiling Unit, The Institute of Cancer ResearchInstitute of Pathology, University Medical Center Hamburg-EppendorfInstitute of Pathology, University Medical Center Hamburg-EppendorfInstitute of Pathology, University Medical Center Hamburg-EppendorfBioinformatics Core, Centre for Evolution and Cancer, The Institute of Cancer ResearchTumour Profiling Unit, The Institute of Cancer ResearchTranslational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer ResearchTumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.https://doi.org/10.1038/s41467-019-13915-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger
spellingShingle	Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer Nature Communications
author_facet	Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger
author_sort	Katharina von Loga
title	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_short	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_full	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_fullStr	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_full_unstemmed	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_sort	extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.
url	https://doi.org/10.1038/s41467-019-13915-7
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Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

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