Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions
We report a case of a pregnant woman with a complex hemoglobinopathy who developed a symptomatic anemia at 28 weeks of gestation and was treated with multiple transfusions of type-specific packed red blood cells. Shortly thereafter, she developed a fever and joint pains, along with laboratory values...
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Online Access: | http://dx.doi.org/10.1155/2013/413502 |
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doaj-f20068cc46ac4476864cec3f140227ac2020-11-24T21:13:24ZengHindawi LimitedCase Reports in Obstetrics and Gynecology2090-66842090-66922013-01-01201310.1155/2013/413502413502Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of TransfusionsDavid Kim0Hector Mendez-Figueroa1Brenna L. Anderson2Department of Obstetrics and Gynecology, Women & Infants Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02905, USAMaternal-Fetal Medicine Clinic, Department of Obstetrics and Gynecology, Women & Infants Hospital, The Warren Alpert Medical School of Brown University, 101 Dudley Street, 3rd Floor, Providence, RI 02905-2401, USAMaternal-Fetal Medicine Clinic, Department of Obstetrics and Gynecology, Women & Infants Hospital, The Warren Alpert Medical School of Brown University, 101 Dudley Street, 3rd Floor, Providence, RI 02905-2401, USAWe report a case of a pregnant woman with a complex hemoglobinopathy who developed a symptomatic anemia at 28 weeks of gestation and was treated with multiple transfusions of type-specific packed red blood cells. Shortly thereafter, she developed a fever and joint pains, along with laboratory values consistent with hemolysis. Timing suggested a delayed transfusion reaction. An extensive evaluation including red blood cell antigen identification and cross-reaction failed to reveal the cause for her hemolysis. Despite her critically low hemoglobin levels, her transfusions were withheld in an attempt to allow the patient to recover conservatively. With this strategy, her hemoglobin remained below her baseline, but her symptoms began to improve. Her laboratory values normalized, and hemolysis was no longer evident. Three weeks later, her hemoglobin levels returned back to her baseline without additional intervention. She went on to deliver a full-term male infant.http://dx.doi.org/10.1155/2013/413502 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Kim Hector Mendez-Figueroa Brenna L. Anderson |
spellingShingle |
David Kim Hector Mendez-Figueroa Brenna L. Anderson Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions Case Reports in Obstetrics and Gynecology |
author_facet |
David Kim Hector Mendez-Figueroa Brenna L. Anderson |
author_sort |
David Kim |
title |
Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions |
title_short |
Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions |
title_full |
Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions |
title_fullStr |
Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions |
title_full_unstemmed |
Pregnancy with a Severe Hemoglobinopathy: Unintended Consequences of Transfusions |
title_sort |
pregnancy with a severe hemoglobinopathy: unintended consequences of transfusions |
publisher |
Hindawi Limited |
series |
Case Reports in Obstetrics and Gynecology |
issn |
2090-6684 2090-6692 |
publishDate |
2013-01-01 |
description |
We report a case of a pregnant woman with a complex hemoglobinopathy who developed a symptomatic anemia at 28 weeks of gestation and was treated with multiple transfusions of type-specific packed red blood cells. Shortly thereafter, she developed a fever and joint pains, along with laboratory values consistent with hemolysis. Timing suggested a delayed transfusion reaction. An extensive evaluation including red blood cell antigen identification and cross-reaction failed to reveal the cause for her hemolysis. Despite her critically low hemoglobin levels, her transfusions were withheld in an attempt to allow the patient to recover conservatively. With this strategy, her hemoglobin remained below her baseline, but her symptoms began to improve. Her laboratory values normalized, and hemolysis was no longer evident. Three weeks later, her hemoglobin levels returned back to her baseline without additional intervention. She went on to deliver a full-term male infant. |
url |
http://dx.doi.org/10.1155/2013/413502 |
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