Speech frequency-following response in human auditory cortex is more than a simple tracking

• Main Authors: Ning Guo, Xiaopeng Si, Yang Zhang, Yue Ding, Wenjing Zhou, Dan Zhang, Bo Hong
• Format: Article
• Language: English
• Published: Elsevier 2021-02-01
• Series: NeuroImage
• Subjects: Frequency-following response; Intracranial EEG; Auditory cortex; Speech; Frequency limits
• Online Access: http://www.sciencedirect.com/science/article/pii/S1053811920310302

The human auditory cortex is recently found to contribute to the frequency following response (FFR) and the cortical component has been shown to be more relevant to speech perception. However, it is not clear how cortical FFR may contribute to the processing of speech fundamental frequency (F0) and the dynamic pitch. Using intracranial EEG recordings, we observed a significant FFR at the fundamental frequency (F0) for both speech and speech-like harmonic complex stimuli in the human auditory cortex, even in the missing fundamental condition. Both the spectral amplitude and phase coherence of the cortical FFR showed a significant harmonic preference, and attenuated from the primary auditory cortex to the surrounding associative auditory cortex. The phase coherence of the speech FFR was found significantly higher than that of the harmonic complex stimuli, especially in the left hemisphere, showing a high timing fidelity of the cortical FFR in tracking dynamic F0 in speech. Spectrally, the frequency band of the cortical FFR was largely overlapped with the range of the human vocal pitch. Taken together, our study parsed the intrinsic properties of the cortical FFR and reveals a preference for speech-like sounds, supporting its potential role in processing speech intonation and lexical tones.