RNA Structures and Their Role in Selective Genome Packaging
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signa...
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1788 |
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doaj-f1f33ddbdbfd4ebb92b21552c10fa2a62021-09-26T01:37:24ZengMDPI AGViruses1999-49152021-09-01131788178810.3390/v13091788RNA Structures and Their Role in Selective Genome PackagingLiqing Ye0Uddhav B. Ambi1Marco Olguin-Nava2Anne-Sophie Gribling-Burrer3Shazeb Ahmad4Patrick Bohn5Melanie M. Weber6Redmond P. Smyth7Genome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, GermanyTo generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.https://www.mdpi.com/1999-4915/13/9/1788RNA virusRNARNA structuregenome packagingviral assemblyevolution |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Liqing Ye Uddhav B. Ambi Marco Olguin-Nava Anne-Sophie Gribling-Burrer Shazeb Ahmad Patrick Bohn Melanie M. Weber Redmond P. Smyth |
| spellingShingle |
Liqing Ye Uddhav B. Ambi Marco Olguin-Nava Anne-Sophie Gribling-Burrer Shazeb Ahmad Patrick Bohn Melanie M. Weber Redmond P. Smyth RNA Structures and Their Role in Selective Genome Packaging Viruses RNA virus RNA RNA structure genome packaging viral assembly evolution |
| author_facet |
Liqing Ye Uddhav B. Ambi Marco Olguin-Nava Anne-Sophie Gribling-Burrer Shazeb Ahmad Patrick Bohn Melanie M. Weber Redmond P. Smyth |
| author_sort |
Liqing Ye |
| title |
RNA Structures and Their Role in Selective Genome Packaging |
| title_short |
RNA Structures and Their Role in Selective Genome Packaging |
| title_full |
RNA Structures and Their Role in Selective Genome Packaging |
| title_fullStr |
RNA Structures and Their Role in Selective Genome Packaging |
| title_full_unstemmed |
RNA Structures and Their Role in Selective Genome Packaging |
| title_sort |
rna structures and their role in selective genome packaging |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2021-09-01 |
| description |
To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution. |
| topic |
RNA virus RNA RNA structure genome packaging viral assembly evolution |
| url |
https://www.mdpi.com/1999-4915/13/9/1788 |
| work_keys_str_mv |
AT liqingye rnastructuresandtheirroleinselectivegenomepackaging AT uddhavbambi rnastructuresandtheirroleinselectivegenomepackaging AT marcoolguinnava rnastructuresandtheirroleinselectivegenomepackaging AT annesophiegriblingburrer rnastructuresandtheirroleinselectivegenomepackaging AT shazebahmad rnastructuresandtheirroleinselectivegenomepackaging AT patrickbohn rnastructuresandtheirroleinselectivegenomepackaging AT melaniemweber rnastructuresandtheirroleinselectivegenomepackaging AT redmondpsmyth rnastructuresandtheirroleinselectivegenomepackaging |
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