Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

TRPC5 channel is a nonselective cation channel that participates in diverse physiological processes. TRPC5 inhibitors show promise in the treatment of anxiety disorder, depression, and kidney disease. However, the binding sites and inhibitory mechanism of TRPC5 inhibitors remain elusive. Here, we pr...

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Bibliographic Details
Main Authors: Kangcheng Song, Miao Wei, Wenjun Guo, Li Quan, Yunlu Kang, Jing-Xiang Wu, Lei Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
TRPC5
clemizole
HC-070
TRPC
Online Access:https://elifesciences.org/articles/63429

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