Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease.

Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease.

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be of limited value. As an attempt to improve the predictive nature of th...

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Bibliographic Details
Main Authors: Ruoqi Peng, Sriram Sridhar, Gaurav Tyagi, Jonathan E Phillips, Rosario Garrido, Paul Harris, Lisa Burns, Lorena Renteria, John Woods, Leena Chen, John Allard, Palanikumar Ravindran, Hans Bitter, Zhenmin Liang, Cory M Hogaboam, Chris Kitson, David C Budd, Jay S Fine, Carla M T Bauer, Christopher S Stevenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3614979?pdf=render

Internet

http://europepmc.org/articles/PMC3614979?pdf=render

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