Plant DNA polymerases α and δ mediate replication of geminiviruses

Geminiviruses cause substantial damage to crops worldwide. Here Wu et al. show that geminivirus replication relies upon the host DNA polymerases α and δ, which produce double-stranded DNA intermediates and new copies of the viral genome, respectively, and is modulated by the viral C3 protein.

Bibliographic Details
Main Authors: Mengshi Wu, Hua Wei, Huang Tan, Shaojun Pan, Qi Liu, Eduardo R. Bejarano, Rosa Lozano-Durán
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23013-2