Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface
During gestation, many different mechanisms act to render the maternal immune system tolerant to semi-allogeneic trophoblast cells of foetal origin, including those mediated via mucins that are expressed during the peri-implantation period in the uterus. Tumour- associated glycoprotein-72 (TAG-72) e...
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Series: | Clinical and Developmental Immunology |
Online Access: | http://dx.doi.org/10.1155/2013/542152 |
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doaj-f1d03d509086436b9c533a88f821e6ac2020-11-24T21:13:24ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/542152542152Mucins Help to Avoid Alloreactivity at the Maternal Fetal InterfaceArnela Redzovic0Gordana Laskarin1Marin Dominovic2Herman Haller3Daniel Rukavina4Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, CroatiaDepartment of Obstetrics and Gynecology, Clinical Hospital, University of Rijeka, Kresimirova 42a, 51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, CroatiaDuring gestation, many different mechanisms act to render the maternal immune system tolerant to semi-allogeneic trophoblast cells of foetal origin, including those mediated via mucins that are expressed during the peri-implantation period in the uterus. Tumour- associated glycoprotein-72 (TAG-72) enhances the already established tolerogenic features of decidual dendritic cells with the inability to progress towards Th1 immune orientation due to lowered interferon (IFN)-γ and interleukin (IL)-15 expression. Mucine 1 (Muc 1) supports alternative activation of decidual macrophages, restricts the proliferation of decidual regulatory CD56+ bright natural killer (NK) cells, and downregulates their cytotoxic potential, including cytotoxic mediator protein expression. Removing TAG-72 and Muc 1 from the eutopic implantation site likely contributes to better control of trophoblast invasion by T cells and NK cells and appears to have important immunologic advantages for successful implantation, in addition to mechanical advantages. However, these processes may lead to uncontrolled trophoblast growth after implantation, inefficient defence against infection or tumours, and elimination of unwanted immunocompetent cells at the maternal-foetal interface. The use of mucins by tumour cells to affect the local microenvironment in order to avoid the host immune response and to promote local tumour growth, invasion, and metastasis confirms this postulation.http://dx.doi.org/10.1155/2013/542152 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arnela Redzovic Gordana Laskarin Marin Dominovic Herman Haller Daniel Rukavina |
spellingShingle |
Arnela Redzovic Gordana Laskarin Marin Dominovic Herman Haller Daniel Rukavina Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface Clinical and Developmental Immunology |
author_facet |
Arnela Redzovic Gordana Laskarin Marin Dominovic Herman Haller Daniel Rukavina |
author_sort |
Arnela Redzovic |
title |
Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface |
title_short |
Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface |
title_full |
Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface |
title_fullStr |
Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface |
title_full_unstemmed |
Mucins Help to Avoid Alloreactivity at the Maternal Fetal Interface |
title_sort |
mucins help to avoid alloreactivity at the maternal fetal interface |
publisher |
Hindawi Limited |
series |
Clinical and Developmental Immunology |
issn |
1740-2522 1740-2530 |
publishDate |
2013-01-01 |
description |
During gestation, many different mechanisms act to render the maternal immune system tolerant to semi-allogeneic trophoblast cells of foetal origin, including those mediated via mucins that are expressed during the peri-implantation period in the uterus. Tumour- associated glycoprotein-72 (TAG-72) enhances the already established tolerogenic features of decidual dendritic cells with the inability to progress towards Th1 immune orientation due to lowered interferon (IFN)-γ and interleukin (IL)-15 expression. Mucine 1 (Muc 1) supports alternative activation of decidual macrophages, restricts the proliferation of decidual regulatory CD56+ bright natural killer (NK) cells, and downregulates their cytotoxic potential, including cytotoxic mediator protein expression. Removing TAG-72 and Muc 1 from the eutopic implantation site likely contributes to better control of trophoblast invasion by T cells and NK cells and appears to have important immunologic advantages for successful implantation, in addition to mechanical advantages. However, these processes may lead to uncontrolled trophoblast growth after implantation, inefficient defence against infection or tumours, and elimination of unwanted immunocompetent cells at the maternal-foetal interface. The use of mucins by tumour cells to affect the local microenvironment in order to avoid the host immune response and to promote local tumour growth, invasion, and metastasis confirms this postulation. |
url |
http://dx.doi.org/10.1155/2013/542152 |
work_keys_str_mv |
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