Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neurito...

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Main Authors: Aurélie Alleaume-Butaux, Simon Nicot, Mathéa Pietri, Anne Baudry, Caroline Dakowski, Philippe Tixador, Hector Ardila-Osorio, Anne-Marie Haeberlé, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneider
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4524729?pdf=render

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