Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses

Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses

The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized three human monoclonal antibodies (mAbs) that neutralize A(H1N1)pdm09 viruses. Generation of escape mutant viruses suggested that these antibodies recognized conserved residues of the receptor-bindin...

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Bibliographic Details
Main Authors: Atsuhiro Yasuhara, Seiya Yamayoshi, Mutsumi Ito, Maki Kiso, Shinya Yamada, Yoshihiro Kawaoka
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
influenza A virus
human monoclonal antibody
HA
antiviral agent
escape mutant virus
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02660/full

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